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1 Strip = 12 Tablets
Beximco Pharmaceuticals LtdProduct Description
Napadol contains the fixed-dose combination of Paracetamol and Tramadol Hydrochloride, a potent analgesic preparation utilized for the management of moderate to severe acute pain, leveraging a multimodal approach to achieve superior therapeutic efficacy. This combination functions through complementary mechanisms: Paracetamol acts primarily as a centrally acting analgesic, likely through the inhibition of cyclooxygenase (COX) enzymes and modulation of descending serotonergic pathways, while Tramadol serves as a centrally acting synthetic opioid that exerts its effect via weak μ-opioid receptor agonism and the inhibition of serotonin and norepinephrine reuptake. By addressing nociceptive signaling through distinct pathways, this synergy allows for effective pain relief at lower individual doses, potentially reducing the incidence of dose-related adverse effects. Despite its efficacy, use must be carefully managed to mitigate risks such as opioid-related side effects—including nausea, dizziness, and constipation—and to avoid the potential for hepatotoxicity associated with the excessive intake of Paracetamol.
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