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Incepta Pharmaceuticals Ltd.Product Description
Telmipress is a potent, long-acting angiotensin II receptor blocker (ARB) primarily used to manage hypertension and reduce the risk of cardiovascular events such as stroke and myocardial infarction. It works by selectively binding to the AT₁ receptor subtype, effectively blocking the vasoconstricting and aldosterone-secreting effects of angiotensin II, which results in systemic vasodilation and lowered blood pressure. Unique among ARBs, Telmisartan also acts as a partial agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ), a nuclear receptor involved in glucose and lipid metabolism, potentially offering additional metabolic benefits like improved insulin sensitivity. Due to its high lipophilicity and a long terminal elimination half-life of approximately 24 hours, it allows for consistent blood pressure control with once-daily dosing.
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