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Square Pharmaceuticals PLCProduct Description
Nebivolol Hydrochloride is a third-generation, highly selective beta-1 adrenergic receptor antagonist used primarily in the management of hypertension and chronic heart failure. It is distinguished from traditional beta-blockers by its unique dual mechanism of action: in addition to blocking beta-1 receptors to reduce heart rate and myocardial contractility, it stimulates the L-arginine/nitric oxide (NO) pathway, leading to systemic vasodilation. This nitric oxide-mediated effect helps improve endothelial function and reduces peripheral vascular resistance with fewer of the typical side effects, such as cold extremities or fatigue, often associated with older generations of the drug class. Formulated as a racemic mixture, its d-enantiomer provides the selective beta-blocking activity while the l-enantiomer contributes to the vasodilation, making it a highly effective and well-tolerated cardiovascular agent.
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