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1 Strip = 10 Tablets
Aristopharma LtdProduct Description
The combination of Vildagliptin and Metformin Hydrochloride is a potent oral antidiabetic therapy used to improve glycemic control in patients with Type 2 Diabetes Mellitus. This dual-action formulation addresses multiple pathophysiological defects of the disease: Vildagliptin is a selective and reversible inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme, which prevents the degradation of incretin hormones like GLP-1, thereby enhancing glucose-dependent insulin secretion and suppressing glucagon release. Metformin complements this by acting as a biguanide that primarily decreases hepatic glucose production (gluconeogenesis), reduces intestinal absorption of glucose, and improves insulin sensitivity in peripheral tissues. This synergy effectively lowers both fasting and postprandial plasma glucose levels with a low risk of hypoglycemia and weight gain. Patients are typically advised to take this medication with meals to minimize gastrointestinal side effects, and it is essential to monitor renal function regularly due to the clearance pathways of metformin.
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