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1 Strip = 10 Tablets
ACI Pharmaceuticals LtdProduct Description
The combination of Olmesartan Medoxomil and Hydrochlorothiazide (HCTZ) is a highly effective dual-action antihypertensive treatment designed to achieve blood pressure targets through complementary physiological pathways. Olmesartan Medoxomil is a potent, long-acting angiotensin II receptor blocker (ARB) that functions as a prodrug; upon ingestion, it is hydrolyzed to olmesartan, which selectively blocks the AT1 receptors. This action inhibits the vasoconstrictive and aldosterone-secreting effects of angiotensin II, leading to systemic vasodilation and reduced peripheral resistance. Hydrochlorothiazide, a thiazide diuretic, complements this by acting on the distal convoluted tubules in the kidneys to inhibit sodium and chloride resorption, thereby increasing water excretion and reducing overall blood volume. The clinical synergy of these two agents is particularly valuable because the diuretic-induced activation of the renin-angiotensin-aldosterone system (RAAS) is effectively counteracted by the ARB component. This multi-pathway approach not only provides superior blood pressure reduction compared to monotherapy but also enhances long-term cardiovascular protection and reduces the risk of stroke and myocardial infarction, typically through a convenient once-daily oral dose.
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