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Renata PLCProduct Description
**Active Composition & Class**
* **Active Ingredient:** Vitamin E (d-alpha tocopherol)
* **Therapeutic Class:** Vitamin E Preparations / Herbal and Nutraceuticals
**Indications**
* Treatment and prevention of Vitamin E deficiency.
* Used as an antioxidant support for various conditions, including:
* Alzheimer’s Disease / Dementia
* Rheumatoid Arthritis pain
* Nerve damage induced by chemotherapy
* Male infertility
* Age-Related Macular Degeneration (AMD)
* Premenstrual Syndrome (PMS) and painful menstrual periods (dysmenorrhea)
* Heart disease (to improve nitrate effectiveness)
* Keratectomy support
**Mechanism of Action**
* Functions as a lipid-soluble antioxidant, protecting cell membranes (polyunsaturated fatty acids) and oxygen-sensitive vitamins (Vitamin A and Vitamin C) from oxidative damage. Prevents deficiency signs like hemolytic anemia, thrombosis, edema, and muscle weakness.
**Dosage & Administration**
* **Age-Related Macular Degeneration:** 400–600 IU daily.
* **Heart Disease (Nitrate Adjunct):** 200 IU 3 times daily.
* **Dementia / Alzheimer’s Disease:** 800–2000 IU 1 to 2 times daily.
* **Rheumatoid Arthritis Pain:** 600 IU daily.
* **Male Infertility:** 200–600 IU daily.
* **Premenstrual Syndrome (PMS):** 400 IU daily.
* **Painful Menstrual Periods:** 200 IU daily.
* **Administration:** Oral softgel/capsule. Take strictly under the guidance of a registered physician.
**Contraindications & Warnings**
* **Contraindications:** Known hypersensitivity to Vitamin E. Also contraindicated in patients with rare hereditary fructose intolerance, glucose-galactose malabsorption, or sucrose-isomaltase insufficiency.
* **Precautions:** May increase bleeding risk in Vitamin K-deficient individuals or those on oral anticoagulants; monitor PT/INR closely. May increase thrombosis risk in susceptible individuals, including women taking estrogen-containing oral contraceptives.
**Side Effects & Interactions**
* **Side Effects:** Generally well-tolerated. High doses (>1000 IU daily) can cause transient GI disturbances, diarrhea, and abdominal pain.
* **Drug Interactions:**
* Potentiates the anticoagulant effect of **Warfarin**.
* May impair absorption of Vitamin A and alter Vitamin K function.
**Pregnancy, Lactation & Storage**
* **Pregnancy & Lactation:** High doses are not recommended during pregnancy (especially the 1st trimester) due to lack of safety evidence. Avoid during lactation as excretion in breast milk is unconfirmed.
* **Storage:** Keep in a cool, dry place away from light and heat. Keep out of reach of children.
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