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tab. Duphaston 10 mg

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tab. Duphaston 10 mg
Hormonal Products

1 strip = 20

UniMed UniHealth Pharmaceuticals Ltd
Generic Name: Dydrogesterone
MRP ৳ 780 4% Off
Best Price ৳ 750
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Product Description

**Active Ingredient & Class**


* **Active Ingredient:** Dydrogesterone (Orally-active synthetic progestogen)

* **Therapeutic Class:** Female Sex Hormones

* **Pharmacology:** Simulates endogenous progesterone to produce a secretory endometrium in an estrogen-primed uterus. Provides protection against estrogen-induced endometrial hyperplasia and cancer without causing androgenic, estrogenic, corticoid, or anabolic side effects.


**Primary Indications**


* **Progesterone Deficiencies:** Threatened or habitual miscarriage, dysmenorrhea, endometriosis, secondary amenorrhea, irregular cycles, dysfunctional uterine bleeding, and luteal insufficiency-related infertility.

* **Assisted Reproductive Technology (ART):** Luteal support during fertility treatments.

* **Hormone Replacement Therapy (HRT):** Protects the endometrium against unopposed estrogen in menopausal women with an intact uterus.


**Key Dosage Guidelines**


| Indication | Standard Dosage Schedule |

| --- | --- |

| **Threatened Miscarriage** | 40 mg (4 tablets) stat, then 10 mg every 8 hours until symptoms resolve. |

| **Habitual Miscarriage** | 10 mg twice daily until the 20th week of pregnancy. |

| **Dysmenorrhea / Endometriosis** | 10 mg twice daily (or 2-3 times daily for endometriosis) from day 5 to day 25 of the cycle. |

| **Dysfunctional Bleeding** | **To arrest bleeding:** 10 mg twice daily for 5–7 days (with estrogen). <br>


<br>**To prevent bleeding:** 10 mg twice daily from day 11 to day 25. |

| **Infertility (Luteal Deficit)** | 10 mg daily from day 14 to day 25 for at least 6 consecutive cycles. |

| **ART Luteal Support** | 10 mg 3 times daily starting on oocyte retrieval day for 10 weeks (if pregnancy confirmed). |

| **Hormone Replacement Therapy** | 10 mg daily for 12–14 days of a 28-day cycle, alongside estrogen therapy. |


**Safety, Warnings & Side Effects**


| Category | Details |

| --- | --- |

| **Contraindications** | Known/suspected progestogen-dependent tumors, undiagnosed vaginal bleeding, severe liver disorders, history of thromboembolic diseases (VTE/stroke/CAD), sickle cell anemia, and hypersensitivity. |

| **Common Side Effects** | Migraines/headaches, nausea, menstrual disturbances (breakthrough bleeding/spotting), and breast tenderness. |

| **Pregnancy & Lactation** | Safe during early pregnancy for indicated uses; **contraindicated during lactation** as dydrogesterone passes into breast milk. |

| **Precautions** | Investigate unexplained bleeding before starting therapy. Immediately discontinue if severe migraines, marked blood pressure spikes, liver failure, or thromboembolic symptoms occur. |


**Storage Conditions**


* Store below 30°C in a dry place, protected from direct light. Keep out of reach of children. Always take under the supervision of a registered physician.

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